CRTgeeDR: an R Package for Doubly Robust Generalized Estimating Equations Estimations in Cluster Randomized Trials

نویسنده

  • Victor De Gruttola
چکیده

Semi-parametric approaches based on generalized estimating equation (GEE) are widely used to analyze correlated outcomes in longitudinal settings. In this paper, we present a package CRTgeeDR developed for cluster randomized trials with missing data (CRTs). For use of inverse probability weighting to adjust for missing data in cluster randomized trials (CRTs), we show that other software lead to biased estimation for non-independence working correlation structure. CRTgeeDR solve this problem. We also extend the ability of existing packages to allow augmented Doubly Robust GEE estimation (DR). Simulations studies demonstrate the consistency of estimators implemented in CRTgeeDR compared to packages such as geepack and the gains associated with the use of the DR for analyzing a binary outcome using a logistic regression. Finally, we illustrate the method on data from a sanitation CRT in developing countries.

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تاریخ انتشار 2017